Description

Fmoc-His(Tos)-Oh is a protected derivative of the amino acid histidine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly when incorporating the complex histidine residue. It is an essential building block for the development of therapeutic peptides, diagnostic reagents, and biochemical research tools in the pharmaceutical and biotechnology sectors.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, sequential assembly of custom peptide sequences.
• Pharmaceutical Research: For the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation & Labeling: Utilized to introduce histidine residues for site-specific conjugation with tags, probes, or other molecules.
• Combinatorial Chemistry: Serves as a building block in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial R&D: Fundamental reagent for studying protein structure-function relationships, enzyme mechanisms, and molecular recognition.

Basic Information

Product Name	Fmoc-His(Tos)-Oh
CAS No.	112380-10-6
Molecular Formula	C33H31N3O7S
Molecular Weight	613.68 g/mol
Synonyms	Fmoc-His(Tos)-OH; N-α-Fmoc-N-π-tosyl-L-histidine; Fmoc-L-histidine(N-π-tosyl)-OH; Fmoc-His(Tos)-OH; 9-Fluorenylmethyloxycarbonyl-N-π-tosyl-L-histidine; Fmoc-His(Tos); Fmoc-Histidine(Tosyl)-OH; Nα-(9-Fluorenylmethoxycarbonyl)-Nim-tosyl-L-histidine
EINECS	Contact for details

Quality Control

Our Fmoc-His(Tos)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.