Description

Diltiazem D4 is a deuterium-labeled isotopologue of the calcium channel blocker Diltiazem, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities that require precise and traceable measurement of Diltiazem and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering reference compound for the accurate quantification of Diltiazem in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Metabolite Identification & Profiling: Used in mass spectrometry to differentiate drug-derived metabolites from endogenous compounds, aiding in metabolic pathway elucidation.
• Method Development & Validation: Serves as a critical component in developing and validating robust, regulatory-compliant analytical methods for pharmaceutical quality control.
• Forensic & Anti-Doping Analysis: Provides a reliable reference for the confirmatory testing of Diltiazem in forensic toxicology and sports anti-doping programs.
• Reference Material for Certified Standards: Acts as a precursor or component in the preparation of certified reference materials (CRMs) for laboratory accreditation and quality assurance.

Basic Information

Product Name	Diltiazem D4
CAS No.	112259-41-3
Molecular Formula	C22H22D4N2O4S
Molecular Weight	414.55 g/mol
Synonyms	(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate D4; Diltiazem-d4; Diltiazem (phenyl-d4); cis-(+)-Diltiazem-d4; 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-, labeled with deuterium; Diltiazem Internal Standard D4
EINECS	Contact for details

Quality Control

Our Diltiazem D4 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical stability. Each batch is analyzed using advanced techniques including NMR and high-resolution mass spectrometry to confirm deuterium incorporation and absence of protiated impurities. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and residual solvent levels is provided to support your regulatory submissions and method validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the product should be handled in a low-humidity environment and the container kept sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.