Description

Desacetyl Diltiazem-D4 is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative analyses in pharmaceutical research and development. It is primarily used by analytical laboratories and pharmaceutical manufacturers for precise method development and quality control testing of diltiazem and its metabolites.

Application

• Internal Standard for LC-MS/MS: Used as a stable, isotopically labeled reference compound for the accurate quantification of diltiazem and its metabolites in complex biological matrices like plasma and serum.
• Pharmaceutical R&D: Supports method development, validation, and pharmacokinetic studies for new drug formulations and generic drug applications.
• Bioanalytical Assays: Enables precise and reproducible results in high-performance liquid chromatography (HPLC) and mass spectrometry analyses, minimizing matrix effects.
• Metabolite Studies: Facilitates the identification and quantification of desacetyl diltiazem and related metabolic pathways in clinical and preclinical research.
• Quality Control & Stability Testing: Employed in GMP environments to monitor the purity, potency, and degradation profiles of active pharmaceutical ingredients (APIs).
• Forensic and Clinical Toxicology: Assists in the precise measurement of diltiazem concentrations for therapeutic drug monitoring and forensic investigations.

Basic Information

Product Name	Desacetyl Diltiazem-D4
CAS No.	112259-40-2
Molecular Formula	C22H22D4N2O4S
Molecular Weight	414.54 g/mol
Synonyms	Diltiazem Desacetyl-D4; Desacetyl Diltiazem (d4); (+)-Desacetyl Diltiazem-D4; 5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate-d4; Diltiazem Metabolite (Desacetyl)-D4; Diltiazem Related Compound D-D4; Diltiazem EP Impurity D-D4; D 888-D4
EINECS	Contact for details

Quality Control

Our Desacetyl Diltiazem-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (by HPLC), isotopic purity, and residual solvents. We adhere to relevant industry standards for reference materials to ensure reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.