Description

Biotin-[2-(2-Pyridyldithio)Ethylamide] is a high-purity, heterobifunctional crosslinking reagent designed for advanced bioconjugation and labeling applications. Its core value lies in the precise conjugation of biotinylated molecules to thiol-containing targets, enabling critical downstream analysis and purification. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay production, where reliable and specific molecular tagging is required.

Application

• Bioconjugation Reagent: For site-specific crosslinking of biotinylated probes, antibodies, or proteins to thiolated surfaces, nanoparticles, or other biomolecules.
• Affinity Chromatography Ligand Synthesis: Used to create immobilized biotin ligands on solid supports for streptavidin/avidin-based purification systems.
• Diagnostic Assay Development: Key component in constructing sensitive ELISA, lateral flow, or other immunoassay formats requiring stable biotin-streptavidin interactions.
• Drug Delivery System Fabrication: Enables the functionalization of drug carriers (e.g., liposomes, polymers) with targeting ligands via disulfide linkages.
• Proteomic Research: Facilitates the labeling and isolation of cysteine-containing proteins or peptides for mass spectrometry analysis.
• Surface Plasmon Resonance (SPR): Used to immobilize biomolecules on sensor chips for real-time interaction studies.
• Cell Biology and Imaging: Conjugation tool for preparing fluorescent or other detectable biotinylated probes for cellular staining and microscopy.

Basic Information

Product Name	Biotin-[2-(2-Pyridyldithio)Ethylamide]
CAS No.	112247-65-1
Molecular Formula	C18H26N4O2S3
Molecular Weight	426.62 g/mol
Synonyms	Biotin-PDP; Biotin-PDPEA; Biotin-PDTP; Biotin-PDPE; Biotin-PDPEA; N-(6-(Biotinamido)hexyl)-3'-(2'-pyridyldithio)propionamide; Biotin-HPDP; Biotinylated PDP; 2-Pyridyldithio Ethylamide Biotin
EINECS	Contact for details

Quality Control

Our Biotin-[2-(2-Pyridyldithio)Ethylamide] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.