Description

4-Succinimidyloxycarbonyl-α-Methyl-Alpha(2-Pyridyldithio)Toluene is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive pyridyldithio group. This compound matters for its ability to create stable, cleavable linkages between proteins, peptides, and other biomolecules, enabling advanced bioconjugation strategies. It is essential for researchers and manufacturers in biopharmaceutical development, antibody-drug conjugate (ADC) production, and diagnostic assay kit formulation who require precise and reversible conjugation chemistry.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key reagent for constructing cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein-Protein Conjugation: Facilitates the site-specific crosslinking of different proteins or peptides for creating bispecific constructs or protein complexes.
• Surface Immobilization: Used to tether biomolecules onto sensor chips, nanoparticles, or chromatographic resins via a disulfide bond that can be cleaved under reducing conditions.
• Diagnostic Reagent Preparation: Employed in the labeling of antibodies, enzymes, or other proteins with reporter molecules (e.g., fluorophores, enzymes) for ELISA, lateral flow assays, and other diagnostics.
• Polymer Modification: Enables the functionalization of polymers or dendrimers with bioactive ligands for targeted drug delivery systems.
• Bioconjugation Research: A versatile tool in academic and industrial R&D for exploring new bioconjugation methodologies and developing novel therapeutic or diagnostic platforms.

Basic Information

Product Name	4-Succinimidyloxycarbonyl-α-Methyl-Alpha(2-Pyridyldithio)Toluene
CAS No.	112241-19-7
Molecular Formula	C19H18N2O5S2
Molecular Weight	418.49 g/mol
Synonyms	SM(PEG)2; SMPT; 4-Succinimidyloxycarbonyl-α-methyl-α-(2-pyridyldithio)toluene; Succinimidyl 4-[(2-Pyridyldithio)methyl]benzoate; N-Succinimidyl 4-((2-pyridyldithio)methyl)benzoate; SMPT Crosslinker; SMPT Reagent; SMPT-PEG2
EINECS	Contact for details

Quality Control

Our 4-Succinimidyloxycarbonyl-α-Methyl-Alpha(2-Pyridyldithio)Toluene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and functional activity testing, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Activity	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.