Description

Pam3 Cys-Ser-(Lys)4, Hydrochloride is a synthetic lipopeptide derivative of bacterial lipoprotein, widely recognized as a potent toll-like receptor 2 (TLR2) agonist. This compound is a critical research tool and a key component in the development of advanced vaccine adjuvants and immunotherapies due to its ability to robustly stimulate innate and adaptive immune responses. It is essential for immunologists, pharmaceutical researchers, and biotech companies focused on vaccine formulation, immunostimulatory studies, and novel therapeutic development.

Application

• Vaccine Adjuvant Research & Development: As a powerful TLR2 agonist, it is used to enhance the immunogenicity of subunit vaccines, including those for viral and bacterial pathogens.
• Immunology & Cell Signaling Studies: A standard reagent for studying TLR2-mediated signaling pathways, macrophage activation, and cytokine production in vitro and in vivo.
• Cancer Immunotherapy: Investigated as an immunostimulatory component in therapeutic cancer vaccines to boost anti-tumor immune responses.
• Antiviral & Antimicrobial Agent Development: Used in research exploring the enhancement of host defense mechanisms against infections.
• Formulation of Liposomal & Nanoparticle Delivery Systems: Incorporated into lipid-based carriers to target immune cells and improve vaccine delivery.
• Reference Standard: Serves as a high-purity analytical standard for quality control in peptide and immunology research laboratories.

Basic Information

Product Name	Pam3 Cys-Ser-(Lys)4, Hydrochloride
CAS No.	112208-04-5
Molecular Formula	C66H124ClN19O15S
Molecular Weight	1499.3 g/mol (Hydrochloride salt)
Synonyms	Pam3CSK4; N-Palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine hydrochloride; Tripalmitoyl-S-glyceryl Cys-Ser-(Lys)4 hydrochloride; TLR2 Agonist Pam3CSK4; Synthetic Lipopeptide TLR2 Ligand; S-[2,3-Bis(palmitoyloxy)propyl]cysteinyl-seryl-lysyl-lysyl-lysyl-lysine hydrochloride; PAM3CYSERLYS4
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Pam3 Cys-Ser-(Lys)4, Hydrochloride is characterized using advanced analytical techniques to confirm identity, purity, and biological activity. Certificates of Analysis (COA) detailing HPLC purity, mass spectrometry (MS) confirmation, endotoxin levels, and biological potency are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Endotoxin Level (LAL)	< 1.0 EU/mg
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.