Description

o-tert-Butyldimethylsilyl-n-Methyl-n-T-Butoxycarbonyl-L-Tyrosine, Methyl Ester is a sophisticated, multi-protected derivative of the amino acid L-tyrosine, designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise control over reactivity and stereochemistry during complex peptide and small molecule synthesis. It is primarily utilized by pharmaceutical R&D teams and fine chemical producers engaged in the development of novel therapeutic agents and bioactive compounds.

Application

• Peptide Synthesis Intermediate: Serves as a key building block in solid-phase and solution-phase peptide synthesis, where its orthogonal protecting groups allow for selective deprotection.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, hormone analogs, and other bioactive molecules targeting GPCRs and enzymatic pathways.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) and tert-butoxycarbonyl (Boc) groups provide stability under a wide range of reaction conditions, making it valuable for multi-step synthetic sequences.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified tyrosine derivatives for studying protein-protein interactions, enzyme mechanisms, and cellular signaling.
• Custom Synthesis & Contract Manufacturing: A vital raw material for CDMOs (Contract Development and Manufacturing Organizations) producing custom peptides and complex organic molecules for clients.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and medicinal chemistry projects.

Basic Information

Product Name	o-tert-Butyldimethylsilyl-n-Methyl-n-T-Butoxycarbonyl-L-Tyrosine, Methyl Ester
CAS No.	112196-58-4
Molecular Formula	C22H37NO6Si
Molecular Weight	439.62 g/mol
Synonyms	N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-O-[(1,1-dimethylethyl)dimethylsilyl]-L-tyrosine methyl ester; Boc-N-Me-Tyr(TBDMS)-OMe; Methyl N-[(tert-butoxy)carbonyl]-N-methyl-O-[tert-butyl(dimethyl)silyl]-L-tyrosinate; Boc-N-methyl-O-(tert-butyldimethylsilyl)-L-tyrosine methyl ester; L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester, O-[tert-butyl(dimethyl)silyl] ether; N-Boc-N-methyl-O-TBDMS-L-tyrosine methyl ester; (S)-Methyl 2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoate
EINECS	Contact for details

Quality Control

Our o-tert-Butyldimethylsilyl-n-Methyl-n-T-Butoxycarbonyl-L-Tyrosine, Methyl Ester is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research and development applications. All batches undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.