Description

β-Amyloid (18-28) CAS NO 112163-49-2 is a synthetic peptide fragment corresponding to residues 18-28 of the human amyloid-beta protein. This specific sequence is a critical research tool for studying the aggregation mechanisms, structural properties, and neurotoxicity associated with Alzheimer's disease pathology. It is essential for scientists and developers in pharmaceutical R&D, diagnostic assay development, and academic neuroscience research who require high-purity, well-characterized peptides for their investigations.

Application

• Biochemical Research: Fundamental studies on amyloid-beta peptide aggregation kinetics, fibril formation, and structure-activity relationships.
• Drug Discovery Screening: Used as a target or reagent in high-throughput screening assays to identify potential therapeutic compounds that inhibit aggregation or disrupt pre-formed fibrils.
• Antibody Development & Characterization: Serves as a key antigen for the production and specificity testing of antibodies used in Alzheimer's disease diagnostic kits and research reagents.
• Toxicity Studies: Evaluation of the cellular and synaptic toxicity mechanisms of specific amyloid-beta domains in neuronal cell cultures and model systems.
• Method Development: A standard for developing and validating analytical methods such as HPLC, LC-MS, and immunoassays for amyloid-beta peptide detection and quantification.
• Teaching & Reference Standard: Used in academic settings as a reference material for courses in biochemistry, neurobiology, and peptide chemistry.

Basic Information

Product Name	β-Amyloid (18-28)
CAS No.	112163-49-2
Molecular Formula	C58H89N17O16
Molecular Weight	1280.4 g/mol
Synonyms	Amyloid β-Protein (18-28); Aβ (18-28); β-Amyloid Peptide (18-28); Amyloid β-Peptide (18-28); H-Val-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-OH; VHHQKLVFFA; Amyloidogenic Peptide Fragment; Alzheimer's Disease Peptide Fragment
EINECS	Contact for details

Quality Control

Every batch of β-Amyloid (18-28) is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our standard grade is characterized to meet the exacting requirements of research and development. Comprehensive testing includes identity confirmation by mass spectrometry, purity assessment by analytical HPLC, and determination of peptide content. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.