Description

Parathyroid Hormone-Related Protein(1-141) is a bioactive polypeptide fragment that mimics the activity of the full-length PTHrP, a key regulator of calcium homeostasis and bone metabolism. This high-purity synthetic peptide is essential for advanced biochemical research and therapeutic development targeting bone disorders and hypercalcemia of malignancy. It is a critical reagent for pharmaceutical R&D, academic research in endocrinology, and the development of diagnostic assays.

Application

• Biomedical Research: Fundamental studies on calcium and phosphate metabolism, bone biology, and the role of PTHrP in cancer progression.
• Drug Discovery & Development: Serving as a reference standard, biological activity calibrator, and target molecule in screening for PTH/PTHrP receptor agonists or antagonists.
• Diagnostic Assay Development: Used as a calibrator and immunogen in the development of immunoassays (e.g., ELISA) for detecting PTHrP levels in clinical samples.
• Cell Culture & In Vitro Studies: Stimulation of osteoblast and osteoclast activity, and investigation of signaling pathways in relevant cell lines.
• Peptide Chemistry & Conjugation: Acts as a base structure for creating labeled derivatives (e.g., biotinylated, fluorescent) for specialized research applications.

Basic Information

Product Name	Parathyroid Hormone-Related Protein(1-141)
CAS No.	112024-78-9
Molecular Formula	C710H1153N203O210S5
Molecular Weight	~16000 Da
Synonyms	PTHrP(1-141); Parathyroid Hormone-like Protein (1-141); PTHLH (1-141); Hypercalcemia of malignancy factor; Osteostatin precursor fragment; Parathymosin; PLP; HHM factor; PTH-related peptide fragment 1-141
EINECS	Contact for details

Quality Control

Every batch of Parathyroid Hormone-Related Protein(1-141) is manufactured and analyzed under strict quality systems. Our products undergo rigorous testing, including multiple orthogonal methods, to ensure identity, purity, and biological activity. A comprehensive Certificate of Analysis (COA) detailing purity (HPLC), peptide content, endotoxin levels, and sterility (where applicable) is provided with each shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Endotoxin	< 10 EU/mg
Biological Activity	Determined by in vitro assay (e.g., cAMP induction)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.