Description

Ciprofibrate-Coenzyme A CAS NO 111900-25-5 is a critical biochemical conjugate formed from the hypolipidemic agent ciprofibrate and coenzyme A, representing a key activated intermediate in metabolic pathways. This compound is essential for researchers investigating the mechanism of action, metabolic fate, and potential off-target effects of fibrate-class pharmaceuticals. It is primarily utilized in advanced pharmaceutical research, metabolite identification studies, and the development of analytical reference standards for bioanalysis.

Application

• Pharmaceutical R&D Reference Standard: Serves as a certified reference material for quantifying ciprofibrate-CoA in in vitro and in vivo metabolism studies.
• Mechanistic Toxicology Studies: Used to investigate the role of acyl-CoA thioester formation in drug-induced mitochondrial dysfunction and hepatotoxicity.
• Enzyme Kinetics & Inhibition Assays: Employed as a substrate or inhibitor in studies of acyl-CoA synthetases and transferases to elucidate specific metabolic interactions.
• Biomarker Development: Acts as a critical standard in LC-MS/MS method development for the detection of drug-CoA adducts as potential safety biomarkers.
• Metabolic Pathway Analysis: Essential for tracing and validating the β-oxidation and peroxisomal proliferation pathways activated by fibrate drugs.

Basic Information

Product Name	Ciprofibrate-Coenzyme A
CAS No.	111900-25-5
Molecular Formula	C₄₀H₆₆N₇O₂₀P₃S
Molecular Weight	1106.0 g/mol (approx.)
Synonyms	Ciprofibroyl-Coenzyme A; Ciprofibroyl-CoA; Ciprofibrate CoA; 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoyl-CoA; Coenzyme A, S-[2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl-1-oxopropoxy]-; Ciprofibrate Acyl-CoA Thioester
EINECS	Contact for details

Quality Control

Our Ciprofibrate-Coenzyme A is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.