Description

4-Hydroxy Propranolol is a key pharmacologically active metabolite of the widely used β-blocker, propranolol. This compound is of significant interest in pharmaceutical research and development, particularly for metabolic studies and as a reference standard in analytical chemistry. It is essential for laboratories and manufacturers engaged in drug metabolism and pharmacokinetics (DMPK) research, quality control of pharmaceutical products, and the development of new therapeutic agents. Its precise characterization is critical for ensuring the safety and efficacy profiles of related pharmaceutical formulations.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantification and qualification of propranolol and its metabolites in drug substances and products.
• Drug Metabolism Studies: A critical analyte in in vitro and in vivo studies to understand the metabolic pathways, bioavailability, and clearance of propranolol.
• Analytical Method Development: Serves as a standard for developing and validating HPLC, LC-MS, and GC-MS methods in bioanalytical and quality control laboratories.
• Pharmacokinetic Research: Employed in research investigating the absorption, distribution, metabolism, and excretion (ADME) properties of β-blocker drugs.
• Impurity Profiling: Used to identify and control related substance impurities in propranolol hydrochloride active pharmaceutical ingredient (API) and finished dosage forms.
• Clinical Toxicology: Acts as a marker in forensic and clinical toxicology analyses for propranolol ingestion.

Basic Information

Product Name	4-Hydroxy Propranolol
CAS No.	111691-89-5
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.35 g/mol
Synonyms	1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol, 4-Hydroxypropranolol; 4'-Hydroxypropranolol; 1-(1-Methylethylamino)-3-(1-naphthalenyloxy)-2-propanol, 4-OH-Propranolol; Propranolol Metabolite I; Propranolol 4-Hydroxy Analog
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Propranolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all test results against stringent in-house specifications. Our quality commitment ensures material suitable for demanding applications in pharmaceutical R&D and as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.