Description

Fmoc-Gla(Otbu)2-Oh is a protected amino acid derivative, specifically an Fmoc-protected γ-carboxyglutamic acid with tert-butyl ester side chains. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of post-translationally modified residues. It is essential for researchers and manufacturers developing peptides and proteins that require precise carboxylation for biological activity, such as those involved in blood coagulation and bone metabolism. The product is supplied as a high-purity intermediate to ensure reliable and reproducible synthesis outcomes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing γ-carboxyglutamic acid (Gla) residues.
• Pharmaceutical Research: Used in the development of therapeutic peptides targeting coagulation factors (e.g., Factor IX, Factor X, Protein C) and bone-related proteins (e.g., Osteocalcin).
• Bioconjugation & Protein Engineering: Serves as a specialized precursor for introducing carboxylation sites into engineered proteins and antibody-drug conjugates (ADCs).
• Chemical Biology Probes: Enables the synthesis of labeled or tagged peptides for studying vitamin K-dependent carboxylation pathways and protein-protein interactions.
• Process Development: Employed in scaling up the production of Gla-containing peptides for preclinical and clinical studies.

Basic Information

Product Name	Fmoc-Gla(Otbu)2-Oh
CAS No.	111662-64-7
Molecular Formula	C34H43NO9
Molecular Weight	609.71 g/mol
Synonyms	Fmoc-γ-carboxy-Glu(OtBu)2-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-γ-carboxy-L-glutamic acid α,γ-bis(1,1-dimethylethyl) ester; Fmoc-L-γ-carboxyglutamic acid α,γ-di-tert-butyl ester; Fmoc-Gla(OtBu)2-OH; Fmoc-γ-Carboxyglutamic Acid(OtBu)2; Nα-Fmoc-Nγ, Oγ'-dicarboxy-L-glutamine α,γ-di-tert-butyl ester; Fmoc-4-carboxy-Glu(OtBu)2-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Gla(Otbu)2-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.