Description

3-Amino-5-[[(2,3-Dihydroxypropyl)Amino]Carbonyl]-2,4,6-Triiodo-Benzoic Acid is a high-purity, tri-iodinated organic compound primarily used as a key intermediate in the synthesis of advanced X-ray contrast media. Its molecular structure is engineered to provide excellent water solubility and targeted biodistribution, which is critical for diagnostic imaging applications. This product is essential for pharmaceutical manufacturers and research institutions developing next-generation non-ionic, low-osmolar contrast agents.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of iopromide, ioversol, and other non-ionic iodinated contrast agents.
• Medical Imaging Research: Used in R&D for developing novel X-ray and computed tomography (CT) contrast media with improved safety profiles.
• Contrast Agent Formulation: Critical precursor in the multi-step synthesis of final injectable contrast agent formulations.
• Chemical Synthesis: Serves as a specialized intermediate for creating complex, iodine-containing aromatic compounds for diagnostic purposes.

Basic Information

Product Name	3-Amino-5-[[(2,3-Dihydroxypropyl)Amino]Carbonyl]-2,4,6-Triiodo-Benzoic Acid
CAS No.	111453-32-8
Molecular Formula	C11H11I3N2O5
Molecular Weight	663.93 g/mol
Synonyms	5-Amino-2,4,6-triiodo-N-(2,3-dihydroxypropyl)isophthalamic Acid; Iopromide Intermediate; Ioversol Intermediate; 3-Amino-5-[(2,3-dihydroxypropyl)carbamoyl]-2,4,6-triiodobenzoic Acid; 2,4,6-Triiodo-3-amino-5-[(2,3-dihydroxypropyl)aminocarbonyl]benzoic Acid; Non-Ionic Contrast Agent Intermediate; Triiodinated Isophthalamic Acid Derivative
EINECS	Contact for details

Quality Control

Our production of this critical pharmaceutical intermediate adheres to strict cGMP guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical methods including HPLC, NMR, and elemental analysis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.