Description

n-(4-Ethynylphenyl)Methanesulfonamide is a specialized organic building block featuring both a sulfonamide group and a terminal alkyne moiety. This unique bifunctional structure makes it a valuable intermediate for the synthesis of more complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought by R&D chemists and process development scientists in the life sciences and specialty chemical sectors for constructing targeted libraries and novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially those targeting enzyme inhibition via the sulfonamide pharmacophore.
• Click Chemistry Reagent: The terminal alkyne group enables efficient, high-yielding Huisgen 1,3-dipolar cycloaddition (click reactions) with azides for bioconjugation and polymer functionalization.
• Material Science Research: Used in the development of novel organic frameworks, polymers, and dendrimers with tailored properties.
• Agrochemical Synthesis: Intermediate in the research and development of new crop protection agents and herbicides.
• Chemical Biology Probes: Serves as a precursor for creating molecular probes to study biological pathways and protein functions.
• Ligand and Catalyst Development: Useful for constructing novel ligands for metal catalysis or as a component in organocatalysts.

Basic Information

Product Name	n-(4-Ethynylphenyl)Methanesulfonamide
CAS No.	111448-81-8
Molecular Formula	C9H9NO2S
Molecular Weight	195.24 g/mol
Synonyms	4-Ethynylbenzenesulfonamide; N-(4-Ethynylphenyl)methanesulfonamide; Methanesulfonamide, N-(4-ethynylphenyl)-; 1-Ethynyl-4-(methylsulfonylamino)benzene; p-Ethynylphenyl methanesulfonamide; 4-(Methanesulfonamido)phenylacetylene; Benzenesulfonamide, 4-ethynyl-
EINECS	Contact for details

Quality Control

Our n-(4-Ethynylphenyl)Methanesulfonamide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.