Description

(S)-(-)-1,1,1-Trifluorodecan-2-Ol CAS NO 111423-27-9 is a high-purity chiral fluorinated alcohol building block, prized for its ability to impart unique physicochemical properties to advanced molecules. Its value lies in the combination of a long alkyl chain with a stereodefined trifluoromethyl carbinol moiety, enabling precise modulation of lipophilicity, metabolic stability, and stereoelectronic effects in target compounds. This material is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require enantiomerically pure intermediates for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in areas targeting central nervous system (CNS) disorders and metabolic diseases, where the trifluoromethyl group enhances bioavailability and binding affinity.
• Agrochemical Active Ingredient Precursor: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorinated segment contributes to improved pest selectivity and environmental persistence profiles.
• Liquid Crystal & Advanced Material Synthesis: Serves as a building block for fluorinated mesogens and specialty polymers, leveraging its alkyl chain and fluorinated group to fine-tune phase behavior, dielectric anisotropy, and surface properties.
• Asymmetric Catalyst & Ligand Development: Employed in the preparation of chiral ligands and organocatalysts for enantioselective synthesis, where its defined stereochemistry is crucial for inducing high enantiomeric excess.
• Probe & Diagnostic Reagent Manufacturing: Utilized in creating fluorinated tags and probes for bioimaging (e.g., 19F MRI) and diagnostic assays due to the distinct NMR signature of the trifluoromethyl group.
• Surface Modification & Specialty Surfactants: Acts as a precursor for fluorosurfactants and surface-modifying agents that provide oil- and water-repellency, low surface tension, and enhanced chemical resistance in coatings and films.

Basic Information

Product Name	(S)-(-)-1,1,1-Trifluorodecan-2-Ol
CAS No.	111423-27-9
Molecular Formula	C10H19F3O
Molecular Weight	212.25 g/mol
Synonyms	(S)-1,1,1-Trifluorodecan-2-ol; (S)-(-)-1,1,1-Trifluoro-2-decanol; (2S)-1,1,1-Trifluorodecan-2-ol; (S)-Trifluoromethyl decyl carbinol; 1,1,1-Trifluoro-2-decanol, (S)-(-)-; (S)-2-Trifluoromethyl-1-decanol; Decyl trifluoromethyl carbinol; F3C-CH(OH)-C9H19 (S-enantiomer)
EINECS	Contact for details

Quality Control

Every batch of (S)-(-)-1,1,1-Trifluorodecan-2-Ol is produced and analyzed under strict quality management protocols to ensure exceptional enantiomeric purity and chemical integrity, critical for sensitive synthetic applications. Our quality commitment includes comprehensive analytical verification via chiral HPLC, GC, NMR, and optical rotation to confirm identity, purity, and stereochemical fidelity. Certificates of Analysis (COA) detailing all relevant specifications are provided with each shipment, and we support customer audits and regulatory documentation needs for pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.