Description

Gly-Arg-Gly-Asp-Ser-Pro-Lys CAS NO 111119-28-9 is a synthetic heptapeptide sequence, a key cell adhesion motif derived from fibronectin and other extracellular matrix proteins. This compound is crucial for research and development in biomaterials and targeted therapeutics due to its specific binding affinity to integrin receptors. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biomedical engineering, and bioconjugation sectors for applications ranging from drug delivery systems to tissue culture scaffolds.

Application

• Biomaterial Surface Functionalization: Coating medical devices, implants, and tissue culture plates to promote specific cell adhesion and growth.
• Drug Delivery Targeting: Conjugating therapeutic agents (e.g., anticancer drugs) to the peptide for integrin-mediated targeted delivery to specific cell types.
• Cell Culture & Tissue Engineering: As a bioactive component in hydrogels and 3D scaffolds to direct stem cell differentiation and tissue regeneration.
• Biochemical Research: Used as a tool compound to study integrin-mediated signaling pathways, cell migration, and angiogenesis in vitro.
• Diagnostic Assay Development: Immobilizing the peptide for use in assays to detect or quantify specific integrin expression.
• Peptide-Based Inhibitor Development: Serving as a lead structure for developing antagonists that block integrin-ligand interactions in pathological processes.

Basic Information

Product Name	Gly-Arg-Gly-Asp-Ser-Pro-Lys
CAS No.	111119-28-9
Molecular Formula	C28H49N13O10
Molecular Weight	711.77 g/mol
Synonyms	GRGDSPK; GRGDSPK Peptide; Fibronectin Fragment (GRGDSPK); Arg-Gly-Asp (RGD)-Containing Peptide; Heptapeptide GRGDSPK; Adhesion Peptide; Cell Adhesion Peptide; Integrin-Binding Peptide; H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH
EINECS	Contact for details

Quality Control

Our Gly-Arg-Gly-Asp-Ser-Pro-Lys is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While typically supplied as a high-purity research grade, we adhere to cGMP principles where applicable to support advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 98.0%
Amino Acid Composition	Conforms
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.