Description

Carbonochloridic Acid, 2,2-Difluoroethyl Ester is a specialized organofluorine building block of significant interest in advanced chemical synthesis. This compound serves as a critical reagent for introducing the 2,2-difluoroethoxycarbonyl functional group, enabling the development of novel molecules with tailored properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoroethyl group can enhance lipophilicity and biological activity.
• Material Science Precursor: Employed in the development of specialty polymers and advanced materials, where its reactive chloroformate group allows for functionalization and cross-linking.
• Organic Synthesis Reagent: Acts as a versatile reagent for the preparation of carbamates, carbonates, and other protected functional groups under mild conditions in complex molecule assembly.
• Fluorine Chemistry Research: An essential tool in academic and industrial laboratories focused on exploring new reactions and properties imparted by strategically placed fluorine atoms.

Basic Information

Product Name	Carbonochloridic Acid, 2,2-Difluoroethyl Ester
CAS No.	111022-16-3
Molecular Formula	C3H3ClF2O2
Molecular Weight	144.51 g/mol
Synonyms	2,2-Difluoroethyl Chloroformate; Chloroformic Acid 2,2-Difluoroethyl Ester; 2,2-Difluoroethyl Carbonochloridate; 2,2-Difluoroethoxycarbonyl Chloride; (2,2-Difluoroethoxy)carbonyl Chloride; Difluoroethyl Chloroformate; EINECS 601-294-6
EINECS	601-294-6

Quality Control

Our Carbonochloridic Acid, 2,2-Difluoroethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by GC/HPLC and identity confirmation (IR, NMR), to ensure high purity and consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical properties is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.