Description

Methanesulfonic Acid, Trifluoro-, 3-Methylbutyl Ester is a specialized fluorinated ester derivative of methanesulfonic acid. This compound is valued for its unique reactivity profile, serving as a versatile building block and reagent in advanced chemical synthesis. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials sectors for introducing the trifluoromethanesulfonate (triflate) group, a powerful leaving group in nucleophilic substitution and cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex molecules via palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Ligand and Catalyst Preparation: Employed for the synthesis of organometallic complexes and specialized ligands used in homogeneous catalysis.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialty fluorinated polymers with enhanced chemical resistance and thermal stability.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex organic frameworks, including natural products and functional materials.
• Electrolyte Additive: Potential application as a high-performance additive in lithium-ion battery electrolytes to improve stability and cycle life.

Basic Information

Product Name	Methanesulfonic Acid, Trifluoro-, 3-Methylbutyl Ester
CAS No.	111016-64-9
Molecular Formula	C6H11F3O3S
Molecular Weight	220.21 g/mol
Synonyms	3-Methylbutyl trifluoromethanesulfonate; Isoamyl triflate; Trifluoromethanesulfonic acid 3-methylbutyl ester; 1-Butanol, 3-methyl-, 1-trifluoromethanesulfonate; Isoamyl trifluoromethanesulfonate; Isoamyl triflate ester; Isoamyl ester of triflic acid
EINECS	Contact for details

Quality Control

Our Methanesulfonic Acid, Trifluoro-, 3-Methylbutyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is sensitive to moisture and strong bases. Keep away from heat, sparks, and open flames. Use appropriate corrosion-resistant storage materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Acidity (Titration)	Contact for details
Specific Gravity (20°C)	~1.25 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.