Description

α-Cgrp (31-37) (Rat) is a synthetic peptide fragment corresponding to amino acids 31-37 of the rat Calcitonin Gene-Related Peptide (CGRP). This high-purity biochemical is a critical research tool for studying the structure, function, and receptor interactions of CGRP, a potent neuropeptide involved in vasodilation and pain signaling. It is essential for pharmaceutical R&D, academic research, and diagnostic development in neuroscience, cardiovascular biology, and migraine research.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies of CGRP-mediated neurotransmission, neurogenic inflammation, and migraine pathophysiology.
• Receptor Binding Assays: Employed in competitive binding studies to characterize CGRP receptor (CGRP1 and CGRP2) affinity and specificity.
• Biochemical Standard: Serves as a high-purity calibrant and control in analytical methods such as HPLC and mass spectrometry for peptide quantification.
• Vascular Biology Studies: Applied in vitro and ex vivo to investigate the vasodilatory effects and mechanisms of CGRP fragments on blood vessels.
• Antibody Production & Immunoassays: Acts as an immunogen for generating specific antibodies or as a coating antigen in ELISA development for CGRP detection.
• Structure-Activity Relationship (SAR) Studies: Utilized to map the bioactive regions of the full-length CGRP peptide and design novel analogs or inhibitors.

Basic Information

Product Name	α-Cgrp (31-37) (Rat)
CAS No.	110953-70-3
Molecular Formula	C36H61N11O10
Molecular Weight	783.94 g/mol
Synonyms	Calcitonin Gene-Related Peptide (31-37), rat; α-CGRP (31-37), rat; CGRP31-37 (rat); H-Val-Tyr-Ile-Arg-Leu-NH2 (rat CGRP fragment); CGRP Fragment (31-37); Tyr-Ile-Arg-Leu-NH2 (31-37 sequence); Neuropeptide Fragment
EINECS	Contact for details

Quality Control

Our α-Cgrp (31-37) (Rat) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.