Description

Substance P, Pro(9)-Met(O2)(11)- is a specific, oxidized analog of the neuropeptide Substance P. This modified peptide is crucial for advanced biochemical research, particularly in studies investigating receptor-ligand interactions, oxidative stress pathways, and signal transduction mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuroscience, inflammation, and pain management.

Application

• Neuroscience Research: Used as a tool compound to study the role of Substance P and its modified forms in the central and peripheral nervous systems.
• Receptor Binding Assays: Employed in competitive binding studies to characterize the specificity and affinity of tachykinin receptors (NK1, NK2, NK3).
• Biochemical Pathway Analysis: Investigates the effects of methionine oxidation on peptide stability, activity, and degradation pathways.
• Pharmaceutical Development: Serves as a reference standard or an intermediate in the development of peptide-based therapeutics targeting neurogenic inflammation and pain.
• Cell Signaling Studies: Applied in vitro to examine intracellular signaling cascades activated by modified neuropeptides.
• Academic Research: A key reagent for universities and research labs exploring peptide chemistry, post-translational modifications, and their biological implications.

Basic Information

Product Name	Substance P, Pro(9)-Met(O2)(11)-
CAS No.	110880-54-1
Molecular Formula	C63H98N18O14S
Molecular Weight	1347.6 g/mol
Synonyms	[Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met(O2)-NH2]; Substance P (5-11), Pro(9)-Met(O2)(11)-; Oxidized Substance P fragment; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met(O2)-NH2; Tachykinin fragment; Neurokinin fragment; [Met(O2)11]-Substance P (5-11)
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of Substance P, Pro(9)-Met(O2)(11)- undergoes rigorous testing, including multiple orthogonal methods for identity confirmation and purity assessment. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data (HPLC, MS) is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.