Description

(n-Me-Phe7)-Neurokinin B is a synthetic, modified neurokinin peptide analog, specifically targeting the neurokinin B (NKB) receptor system. This compound is a critical research tool for studying the physiological and pathological roles of the NKB/NK3 receptor pathway, which is involved in processes such as hormone secretion, neuronal signaling, and inflammation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, endocrinology, and drug discovery programs.

Application

• Neuroscience Research: Used as a selective agonist or reference standard to investigate the function of the neurokinin B (NK3) receptor in the central and peripheral nervous systems.
• Endocrinological Studies: Applied in research exploring the role of NKB in the regulation of gonadotropin-releasing hormone (GnRH) and reproductive hormone dynamics.
• Drug Discovery & Development: Serves as a key pharmacological tool for screening, validating, and characterizing new therapeutic compounds targeting the NK3 receptor for conditions like schizophrenia, depression, and hormone-related disorders.
• Biochemical Assays: Employed as a standard in receptor binding assays, functional cell-based assays (e.g., calcium flux), and signal transduction studies to determine agonist/antagonist activity.
• Academic & Preclinical Research: Supports fundamental research into pain pathways, inflammatory responses, and other physiological processes modulated by tachykinin peptides.

Basic Information

Product Name	(n-Me-Phe7)-Neurokinin B
CAS No.	110880-53-0
Molecular Formula	C58H85N15O13S
Molecular Weight	1224.5 g/mol
Synonyms	Neurokinin B (7-(N-methylphenylalanine)); [N-Me-Phe7]-NKB; Asp-Met-His-Asp-Phe-Phe-N-Me-Phe-Gly-Leu-Met-NH2; Modified Neurokinin B; Tachykinin, N-methyl-Phe7-substituted; NK3 Receptor Agonist (modified); H-Asp-Met-His-Asp-Phe-Phe-N-Me-Phe-Gly-Leu-Met-NH2
EINECS	Contact for details

Quality Control

Our (n-Me-Phe7)-Neurokinin B is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.