Description

H-Arginyl-2-(2-Nitrophenylsulfenyl)Tryptophan Methyl Ester is a specialized protected dipeptide building block used in advanced organic synthesis. This compound matters for its role as a key intermediate in the production of complex peptides and peptidomimetics, where selective protection of functional groups is critical. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the fields of oncology and metabolic disorders.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial, protected arginine-tryptophan dipeptide unit for the controlled assembly of longer peptide chains.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs targeting specific biological pathways.
• Bioconjugation Chemistry: Acts as a precursor for creating peptide conjugates with other molecules like dyes, polymers, or drug payloads.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms where specific peptide sequences are required.
• Process Development: Utilized in scaling up synthetic routes for bioactive peptides under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	H-Arginyl-2-(2-Nitrophenylsulfenyl)Tryptophan Methyl Ester
CAS No.	110800-95-8
Molecular Formula	C27H34N8O5S
Molecular Weight	582.68 g/mol
Synonyms	Arg(Nps)-Trp-OMe; H-Arg(Nps)-Trp-OMe; Nα-[(2-Nitrophenyl)sulfenyl]-Nω-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-arginyl-L-tryptophan methyl ester (related protected form); L-Arginyl-2-[(2-nitrophenyl)thio]-L-tryptophan methyl ester; Protected Arg-Trp dipeptide; NPS-Arg-Trp-OMe; 2-(2-Nitrophenylsulfenyl)tryptophan arginine methyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material that meets high-purity specifications suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC are available upon request. Our quality system is designed to support cGMP requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.