Description

(2S,3'Z)-Cefprozil is a key chiral intermediate and the active isomer in the synthesis of the second-generation, broad-spectrum cephalosporin antibiotic, Cefprozil. This high-purity intermediate is critical for ensuring the final API's efficacy, safety, and regulatory compliance. It is primarily required by pharmaceutical manufacturers and advanced R&D facilities engaged in the production of high-value β-lactam antibiotics.

Application

• Primary Pharmaceutical Intermediate: Essential for the synthesis of the antibiotic Cefprozil API.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the final chemical synthesis and purification steps to produce the finished drug substance.
• Research & Development: Serves as a critical reference standard and building block in medicinal chemistry for developing new cephalosporin derivatives.
• Quality Control & Analytical Standards: Employed as a high-purity standard in HPLC, LC-MS, and other analytical methods for assay and impurity profiling.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs specializing in antibiotic production under cGMP guidelines.

Basic Information

Item	Detail
Product Name	(2S,3'Z)-Cefprozil
CAS No.	110764-35-7
Molecular Formula	C18H19N3O5S
Molecular Weight	389.43 g/mol
Synonyms	Cefprozil (Z)-Isomer; (Z)-Cefprozil; (6R,7R)-7-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(Z)-1-propen-1-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefzil intermediate; BMY-28100 isomer; Procef intermediate
EINECS	Contact for details

Quality Control

Our (2S,3'Z)-Cefprozil is manufactured and tested to meet stringent pharmaceutical-grade standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) that includes data for identity, purity, chiral purity, and specified impurities. We ensure compliance with relevant ICH guidelines and support our partners in meeting their regulatory (e.g., FDA, EMA) submission requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (2S,3'Z)-Isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.