Description

n-α-Boc-(R)-2-Amino-3-(Dimethylamino)Propionic Acid is a protected amino acid derivative of significant value in advanced organic synthesis. This compound serves as a crucial chiral building block for the construction of complex molecules, particularly peptides and peptidomimetics. It is primarily sought after by research institutions and pharmaceutical companies engaged in drug discovery and development, especially for creating novel therapeutic agents and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a dimethylamino-functionalized amino acid residue with orthogonal protection.
• Chemical Biology Research: Employed in the design and synthesis of peptide-based probes, inhibitors, and tools for studying biological mechanisms.
• Prodrug Development: Useful for creating prodrugs where the Boc-protected amine and dimethylamino group can be leveraged for targeted delivery or improved pharmacokinetics.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	n-α-Boc-(R)-2-Amino-3-(Dimethylamino)Propionic Acid
CAS No.	110755-32-3
Molecular Formula	C₁₀H₂₀N₂O₄
Molecular Weight	232.28 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3-(dimethylamino)propanoic acid; Boc-Dap(DMA)-OH; Boc-(R)-2,3-Diaminopropionic Acid(DMA) derivative; N-Boc-3-(dimethylamino)-D-alanine; tert-Butyl (R)-2-amino-3-(dimethylamino)propanoate carboxylic acid; (R)-3-(Dimethylamino)-2-((tert-butoxycarbonyl)amino)propanoic acid; Boc-D-Dap(NMe2)-OH
EINECS	Contact for details

Quality Control

Our n-α-Boc-(R)-2-Amino-3-(Dimethylamino)Propionic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.