Description

D-Valine, n-(1-Oxo-2,4-Hexadienyl)-, (E,E)- (9Ci) is a specialized, non-proteinogenic amino acid derivative featuring a conjugated dienone moiety. This compound is valued for its role as a chiral building block and a key intermediate in the synthesis of complex bioactive molecules, particularly in pharmaceutical research. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide mimetics, and advanced chemical probes. The precise stereochemistry and functional groups make it a critical reagent for asymmetric synthesis and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for peptide-based drugs and enzyme inhibitors.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies and for probing biological pathways due to its specific D-configuration and reactive dienone group.
• Peptide Chemistry: Serves as a protected or modified amino acid residue for the solid-phase or solution-phase synthesis of non-natural peptides and peptidomimetics.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Chemical Biology Tool: Utilized in the design and synthesis of activity-based probes (ABPs) and photoaffinity labels for target identification and validation.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Item	Details
Product Name	D-Valine, n-(1-Oxo-2,4-Hexadienyl)-, (E,E)- (9Ci)
CAS No.	110660-90-7
Molecular Formula	C11H17NO3
Molecular Weight	211.26 g/mol
Synonyms	(E,E)-N-(1-Oxo-2,4-hexadienyl)-D-valine; D-Valine, N-(1-oxo-2,4-hexadienyl)-, (E,E)-; (2E,4E)-N-(1-Oxohexa-2,4-dien-1-yl)-D-valine; (E,E)-D-Valine hexadienoyl derivative; N-Sorboyl-D-valine; N-[(1E,3E)-1-Oxo-1,3-hexadien-1-yl]-D-valine; N-(2,4-Hexadienoyl)-D-valine
EINECS	Contact for details

Quality Control

Every batch of D-Valine, n-(1-Oxo-2,4-Hexadienyl)-, (E,E)- (9Ci) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements of research and pre-clinical development. A detailed Certificate of Analysis (COA) including results for assay, chiral purity, and related substances is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under inert atmosphere at lower temperatures (e.g., -20°C) to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.