Description

L-4-Hydroxyphenyl(Alanine-2-13C) is a stable isotope-labeled analog of the amino acid L-tyrosine, specifically labeled with carbon-13 at the 2-position of the alanine moiety. This compound is an essential tool for advanced research and development, providing a non-radioactive tracer for precise metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical researchers, analytical chemists, and diagnostic developers in the fields of proteomics, metabolic pathway analysis, and the development of novel therapeutics and biomarkers.

Application

• Isotope-Labeled Internal Standards: For use in quantitative mass spectrometry (LC-MS/MS, GC-MS) to ensure accurate measurement of L-tyrosine and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: As a stable isotopic tracer in biomedical research to elucidate tyrosine metabolism, neurotransmitter synthesis (dopamine, norepinephrine), and protein turnover studies.
• Pharmaceutical R&D: In the development and validation of assays for new drug candidates that interact with tyrosine metabolic pathways or as a labeled precursor in radioligand synthesis.
• Clinical Diagnostics: For the accurate quantification of tyrosine and its derivatives in patient samples to diagnose inborn errors of metabolism such as tyrosinemia.
• Proteomics Research: Employed in Stable Isotope Labeling by Amino acids in Cell culture (SILAC) experiments for comparative protein expression analysis.
• Nutritional Science Studies: To investigate protein metabolism, amino acid absorption, and utilization in nutritional and physiological research.

Basic Information

Product Name	L-4-Hydroxyphenyl(Alanine-2-13C)
CAS No.	110622-46-3
Molecular Formula	C9H11NO3 (with 13C at specified position)
Molecular Weight	Contact for details
Synonyms	L-Tyrosine-2-13C; (2S)-2-Amino-3-(4-hydroxyphenyl)propanoic-2-13C acid; L-Tyrosine (alanine-2-13C); 4-Hydroxy-L-phenylalanine-2-13C; L-β-(4-Hydroxyphenyl)alanine-2-13C; (S)-2-Amino-3-(4-hydroxyphenyl)propionic-2-13C acid; L-Tyr-2-13C; Stable Isotope Labeled L-Tyrosine
EINECS	Contact for details

Quality Control

Our L-4-Hydroxyphenyl(Alanine-2-13C) is manufactured under strict quality control protocols to ensure high chemical and isotopic purity, critical for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 13C), chemical purity (by HPLC), chiral purity, and identification. We adhere to relevant industry standards for fine chemicals and stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chiral Purity ([α]D)	≥ 99.0% L-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.