Description

D-Proline, 5-(1-Methylethyl)-, cis- (9Ci) is a non-proteinogenic, chiral proline derivative characterized by its unique stereochemistry and isopropyl substitution at the 5-position. This compound matters as a sophisticated chiral building block and ligand, enabling the synthesis of complex molecules with precise three-dimensional control. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in asymmetric synthesis, catalysis, and medicinal chemistry.

Application

• As a chiral ligand or catalyst in asymmetric synthesis and organocatalysis.
• As a key chiral building block for the synthesis of novel pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• In the research and development of peptidomimetics and conformationally constrained peptides.
• For use in agrochemical research for creating enantiomerically pure active compounds.
• As a specialty reagent in academic and industrial research exploring new synthetic methodologies.
• Potential use in the preparation of chiral ionic liquids or specialty materials.

Basic Information

Product Name	D-Proline, 5-(1-Methylethyl)-, cis- (9Ci)
CAS No.	110452-53-4
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(2S,5S)-5-Isopropylproline; cis-5-Isopropyl-D-proline; (2S,5S)-5-(1-Methylethyl)-2-pyrrolidinecarboxylic acid; D-5-Isopropylproline; (2S,5S)-5-Isopropyl-2-pyrrolidinecarboxylic acid; (S,S)-5-Isopropylproline; 5-Isopropyl-D-proline; L-5-Isopropylproline (enantiomer)
EINECS	Contact for details

Quality Control

Our D-Proline, 5-(1-Methylethyl)-, cis- (9Ci) is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including chiral purity verification, to meet the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.