Description

n-Methylparoxetine is a key pharmaceutical intermediate and a derivative of the selective serotonin reuptake inhibitor (SSRI) paroxetine. This compound is of significant value in the research and development of new therapeutic agents targeting central nervous system disorders. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel paroxetine analogs and other SSRIs for potential therapeutic use.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new compounds with improved efficacy and safety profiles.
• Process Development & Scale-Up: Serves as a reference standard and starting material for optimizing synthetic routes in pilot and commercial-scale production.
• Analytical Reference Standard: Employed in quality control laboratories for method development, validation, and impurity profiling of related active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in studies investigating the mechanism of action and metabolic pathways of serotonin reuptake inhibitors.

Basic Information

Item	Detail
Product Name	n-Methylparoxetine
CAS No.	110429-36-2
Molecular Formula	C20H23FNO3
Molecular Weight	344.40 g/mol
Synonyms	N-Methylparoxetine; (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine; 1-Methylparoxetine; Paroxetine N-methyl derivative; trans-N-Methylparoxetine; BRL 29060; FG 7051
EINECS	Contact for details

Quality Control

Every batch of n-Methylparoxetine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency of the product, which is suitable for research and development purposes. A Certificate of Analysis (COA) detailing specifications such as assay, chiral purity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (trans-isomer)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.