Description

Paroxetine-D4 HCl is a deuterium-labeled analog of the widely prescribed antidepressant paroxetine, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and bioequivalence studies. It is an essential tool for pharmaceutical research and development, quality control laboratories, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Primary application for the precise quantification of paroxetine in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of paroxetine.
• Bioanalytical Method Development: Essential for developing and validating robust, high-sensitivity analytical methods in compliance with FDA and ICH guidelines.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and bioequivalence studies for generic drug development.
• Forensic and Toxicology Analysis: Enables accurate detection and quantification of paroxetine in forensic investigations.
• Quality Control & Stability Testing: Used by API and finished dosage form manufacturers to ensure product purity and consistency.

Basic Information

Item	Detail
Product Name	Paroxetine-D4 HCl
CAS No.	110429-35-1
Molecular Formula	C19H16D4FNO3·HCl
Molecular Weight	365.84 g/mol (approx.)
Synonyms	(-)-trans-4-(4-Fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]piperidine-d4 hydrochloride; Paroxetine D4 Hydrochloride; Paroxetine-(phenyl-d4) HCl; 6-Deuterio-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-d3 hydrochloride; BRL 29060-d4; Aropax-d4; Paxil-d4; Seroxat-d4
EINECS	Contact for details

Quality Control

Our Paroxetine-D4 HCl is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We adhere to relevant industry standards to guarantee reliable performance as an internal standard.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.