Description

Boc-Gly-Pro-Pna is a protected tripeptide derivative, specifically a chromogenic substrate, widely used in biochemical and pharmaceutical research. Its core value lies in its role as a key intermediate and substrate for studying enzyme kinetics, particularly for proteases like dipeptidyl peptidase IV (DPP-IV). This compound is essential for researchers and manufacturers in the fields of pharmaceutical development, proteomics, and diagnostic assay design, where precise biochemical tools are required.

Application

• Protease Activity Assays: Primary substrate for the spectrophotometric detection and kinetic analysis of dipeptidyl peptidase IV (DPP-IV) and related proline-specific enzymes.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of more complex peptide-based drug candidates and inhibitors targeting metabolic disorders.
• Biochemical Research: Used in academic and industrial laboratories to investigate enzyme mechanisms, substrate specificity, and inhibitor screening.
• Diagnostic Reagent Manufacturing: Incorporated into kits and reagents for clinical diagnostics, particularly for assays measuring DPP-IV activity relevant to diabetes and immune function research.
• Peptide Library Construction: Acts as a specialized component in the synthesis of focused peptide libraries for high-throughput screening (HTS) applications.

Basic Information

Product Name	Boc-Gly-Pro-Pna
CAS No.	110261-42-2
Molecular Formula	C19H26N4O6
Molecular Weight	406.44 g/mol
Synonyms	Boc-Gly-Pro-pNA; t-Butoxycarbonyl-Glycyl-Prolyl-p-Nitroanilide; N-(tert-Butoxycarbonyl)glycyl-L-prolyl 4-nitroanilide; Glycylproline p-nitroanilide, N-Boc-; Boc-Gly-Pro-4-nitroanilide; DPP-IV Substrate; H-Gly-Pro-pNA, Boc-; Substrate for Dipeptidyl Peptidase IV
EINECS	Contact for details

Quality Control

Our Boc-Gly-Pro-Pna is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development work. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.