Description

5'-Tosyl-2'-Deoxy Guanosine is a key nucleoside derivative where the 5'-hydroxyl group is protected by a tosyl moiety. This modification is critical for controlling reactivity in synthetic pathways, making it an essential building block for the controlled synthesis of oligonucleotides and nucleoside analogs. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic probes, and advanced biochemical research.

Application

• Oligonucleotide Synthesis: Serves as a protected intermediate in the solid-phase and solution-phase synthesis of DNA and RNA sequences for research and therapeutic applications.
• Antiviral & Anticancer Prodrug Development: Used as a precursor in the synthesis of nucleoside analogs that act as potential antiviral agents (e.g., against herpesviruses) or chemotherapeutic drugs.
• Biochemical Research: Employed in studies of enzyme mechanisms, particularly those involving nucleoside kinases and polymerases, and in the preparation of labeled nucleotides.
• Diagnostic Probe Manufacturing: Acts as a starting material for creating fluorescently tagged or otherwise modified nucleosides used in diagnostic assays and genomic research tools.
• Pharmaceutical Intermediates: A crucial synthetic intermediate in the multi-step production of complex active pharmaceutical ingredients (APIs) targeting various diseases.

Basic Information

Product Name	5'-Tosyl-2'-Deoxy Guanosine
CAS No.	109954-64-5
Molecular Formula	C₁₉H₂₃N₅O₇S
Molecular Weight	465.48 g/mol
Synonyms	2'-Deoxyguanosine 5'-(4-methylbenzenesulfonate); Guanosine, 2'-deoxy-, 5'-(p-toluenesulfonate); 5'-O-Tosyl-2'-deoxyguanosine; 2'-Deoxy-5'-O-tosylguanosine; dG-Tosyl; 5'-Tosyl-dG; 2'-Deoxyguanosine 5'-tosylate; 5'-O-(4-Methylbenzenesulfonyl)-2'-deoxyguanosine
EINECS	Contact for details

Quality Control

Our 5'-Tosyl-2'-Deoxy Guanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.