Description

Cyclobutanecarbonitrile, 2-Acetyl-3,3-Dimethyl-, trans- (9Ci) is a specialized, high-purity nitrile derivative with a unique sterically hindered cyclobutane structure. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in sophisticated organic synthesis. It is essential for research and production teams in the pharmaceutical, agrochemical, and fine chemical sectors who require precise molecular frameworks for developing novel active compounds. Our supply is backed by stringent quality control to ensure batch-to-batch consistency for your most demanding R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders or requiring specific steric profiles.
• Agrochemical Synthesis: Used as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: The nitrile and ketone functional groups make it a valuable starting material for synthesizing specialized ligands used in asymmetric catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of flavors, fragrances, and other high-value specialty chemicals.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of advanced polymers with specific thermal or mechanical properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including ring-forming reactions and functional group transformations.

Basic Information

Product Name	Cyclobutanecarbonitrile, 2-Acetyl-3,3-Dimethyl-, trans- (9Ci)
CAS No.	109900-64-3
Molecular Formula	C9H13NO
Molecular Weight	151.21 g/mol
Synonyms	trans-2-Acetyl-3,3-dimethylcyclobutanecarbonitrile; 2-Acetyl-3,3-dimethylcyclobutanecarbonitrile (trans-); (1R,2S)-rel-2-Acetyl-3,3-dimethylcyclobutanecarbonitrile; 3,3-Dimethyl-2-acetylcyclobutanecarbonitrile; Cyclobutanecarbonitrile, 2-acetyl-3,3-dimethyl-, trans-; 109900-64-3; (trans)-2-Acetyl-3,3-dimethyl-1-cyclobutanecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of Cyclobutanecarbonitrile, 2-Acetyl-3,3-Dimethyl-, trans- (9Ci) is produced and verified under a cGMP-compliant quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with stringent industry standards for purity, identity, and consistency. Comprehensive Certificates of Analysis (COA) detailing purity (typically >97% by HPLC), enantiomeric excess, and impurity profiles are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.