Description

Pyrrolidine, 1-(Difluoroacetyl)- (9Ci) is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel pharmaceuticals and agrochemicals, where the introduction of a difluoroacetyl group onto the pyrrolidine scaffold can dramatically alter biological activity and metabolic stability. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorinated moiety can enhance bioavailability and environmental persistence.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis, leveraging the pyrrolidine core's structural features.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of specialty polymers and advanced materials with unique surface properties.
• Fluorine Chemistry Research: A valuable substrate for studying the reactivity of difluoroacetyl groups and for introducing fluorine atoms into complex molecular architectures.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for investigating enzyme mechanisms and biological pathways.

Basic Information

Item	Details
Product Name	Pyrrolidine, 1-(Difluoroacetyl)- (9Ci)
CAS No.	109872-83-5
Molecular Formula	C6H9F2NO
Molecular Weight	149.14 g/mol
Synonyms	1-(Difluoroacetyl)pyrrolidine; N-(Difluoroacetyl)pyrrolidine; Pyrrolidine, 1-(difluoroacetyl)-; Difluoroacetic acid pyrrolidide; N-Pyrrolidyldifluoroacetamide
EINECS	Contact for details

Quality Control

Our Pyrrolidine, 1-(Difluoroacetyl)- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and GC-MS, NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.