Description

D-Threo-1-Phenyl-2-Decanoylamino-3-Morpholino-1-Propanol Hydrochloride is a high-purity, enantiomerically defined chemical building block of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate and a potential pharmacologically active agent, particularly in the study of enzyme inhibition and metabolic pathways. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of novel therapeutic candidates and biochemical probes.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard, inhibitor, or substrate analog in enzymatic studies and metabolic pathway investigations.
• Glycosylceramide Synthase Inhibition: Acts as a potential inhibitor for research into lysosomal storage disorders and related metabolic diseases.
• Academic & Discovery Chemistry: Serves as a valuable starting material for medicinal chemistry programs aiming to develop new therapeutic agents.
• Process Development & Scale-up: Employed in optimizing synthetic routes from laboratory to pilot and commercial scale production.
• Quality Control & Analytical Standards: Provides a high-purity standard for method development, validation, and impurity profiling in analytical laboratories.

Basic Information

Item	Details
Product Name	D-Threo-1-Phenyl-2-Decanoylamino-3-Morpholino-1-Propanol Hydrochloride
CAS No.	109836-82-0
Molecular Formula	C29H50ClN2O3
Molecular Weight	509.18 g/mol
Synonyms	D-threo-PDMP hydrochloride; 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride (D-threo-); D-threo-1-Phenyl-2-decanamido-3-morpholinopropan-1-ol hydrochloride; PDMP HCl (D-threo-); DL-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride (isomeric mixture); Glucosylceramide synthase inhibitor; GCS inhibitor; (1R,2R)-1-Phenyl-2-(decanoylamino)-3-morpholinopropan-1-ol hydrochloride
EINECS	Contact for details

Quality Control

Our D-Threo-1-Phenyl-2-Decanoylamino-3-Morpholino-1-Propanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (D-threo isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.