Description

L-Threo-1-Phenyl-2-Decanoylamino-3-Morpholino-1-Propanol Hcl CAS NO 109836-81-9 is a high-purity, chiral morpholino-propanol derivative used as a critical intermediate in advanced pharmaceutical synthesis. This compound is valued for its role in the research and development of enzyme inhibitors and other bioactive molecules targeting metabolic pathways. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in producing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of glucosylceramide synthase (GCS) inhibitors and other investigational drugs.
• Biochemical Research: Used as a reference standard or tool compound in enzymatic studies and metabolic pathway analysis.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of complex active molecules for preclinical and clinical studies.
• Academic Research: Employed in university and institutional labs for medicinal chemistry projects and pharmacological mechanism exploration.
• Process Chemistry: Utilized in scaling up synthetic routes and optimizing production processes for candidate drugs.

Basic Information

Product Name	L-Threo-1-Phenyl-2-Decanoylamino-3-Morpholino-1-Propanol Hydrochloride
CAS No.	109836-81-9
Molecular Formula	C23H39ClN2O2
Molecular Weight	410.02 g/mol
Synonyms	L-Threo-PDMP hydrochloride; 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride (L-threo form); D-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol HCl (enantiomer); PDMP HCl; (2S,3R)-1-Phenyl-2-(decanoylamino)-3-morpholin-4-ylpropan-1-ol hydrochloride; Glucosylceramide Synthase Inhibitor; GCS Inhibitor; (1S,2R)-1-Phenyl-2-(decanoylamino)-3-morpholinopropan-1-ol hydrochloride
EINECS	Contact for details

Quality Control

Our L-Threo-1-Phenyl-2-Decanoylamino-3-Morpholino-1-Propanol Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research-grade and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Threo isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.