Description

Prepro-Thyrotropin Releasing Hormone (53-74) CAS NO 109796-64-7 is a synthetic peptide fragment corresponding to a specific sequence of the prepro-thyrotropin-releasing hormone precursor. This high-purity peptide is essential for advanced biochemical research and pharmaceutical development, particularly in the study of neuroendocrine signaling pathways and hormone processing. It is primarily utilized by research institutions, biotechnology companies, and pharmaceutical developers focused on endocrinology, neuroscience, and peptide-based therapeutic discovery.

Application

• Biochemical Research: Used as a critical reference standard and tool for studying the biosynthesis, processing, and function of thyrotropin-releasing hormone (TRH).
• Neuroendocrine Studies: Applied in investigations of hypothalamic-pituitary-thyroid axis regulation and related neurological disorders.
• Pharmaceutical R&D: Serves as a key intermediate or analytical standard in the development of diagnostic assays and potential peptide therapeutics.
• Academic Research: Utilized in university and institutional labs for fundamental research in molecular biology, endocrinology, and peptide chemistry.
• Quality Control: Employed as a certified reference material (CRM) for the calibration of analytical instruments and validation of testing methods in QC laboratories.

Basic Information

Product Name	Prepro-Thyrotropin Releasing Hormone (53-74)
CAS No.	109796-64-7
Molecular Formula	C115H179N41O33
Molecular Weight	2608.9 g/mol
Synonyms	Prepro-TRH (53-74); TRH Precursor Peptide (53-74); pGlu-His-Pro-Gly-Lys-Arg-Asn-Gln-Gln-Gly-Asn-Ser-Asn-Gly-Glu-Arg-Gly-Gln-Ala-Gln-Gln-Ala; Thyrotropin-Releasing Hormone Precursor Fragment 53-74; Prepro-thyrotropin-releasing hormone 53-74; pGlu-His-Pro-Gly-Lys-Arg-Asn-Gln-Gln-Gly-Asn-Ser-Asn-Gly-Glu-Arg-Gly-Gln-Ala-Gln-Gln-Ala-OH
EINECS	Contact for details

Quality Control

Our Prepro-Thyrotropin Releasing Hormone (53-74) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical results is provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and avoid repeated freeze-thaw cycles to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Amino Acid Composition	±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.