Description

Gastrin-Releasing Peptide 10, Ala(6)- is a synthetic peptide analog of the gastrin-releasing peptide (GRP) sequence, specifically modified with an alanine substitution at position 6. This compound is a critical research tool for studying the role of GRP and its receptor (GRPR) in various physiological and pathological processes. It is primarily utilized by researchers and pharmaceutical developers in the fields of neurobiology, oncology, and gastrointestinal research to investigate signaling pathways, receptor binding, and potential therapeutic targets.

Application

• Biomedical Research: Used as a specific ligand to study the binding affinity, signaling mechanisms, and biological functions of the Gastrin-Releasing Peptide Receptor (GRPR).
• Neuropharmacology: Investigation of GRP's role in the central nervous system, including studies on satiety, stress response, and circadian rhythms.
• Oncology Research: Exploration of GRPR expression and function in various cancers (e.g., prostate, lung, breast) for diagnostic and therapeutic development.
• Gastrointestinal Physiology: Research into the peptide's effects on gastric acid secretion, smooth muscle contraction, and mucosal growth.
• Peptide Chemistry & Drug Discovery: Serves as a reference standard, intermediate, or lead compound in the design and synthesis of novel peptide-based pharmaceuticals.
• Diagnostic Development: Potential use in the development of imaging probes or assays targeting GRPR-positive tissues.

Basic Information

Product Name	Gastrin-Releasing Peptide 10, Ala(6)-
CAS No.	109708-38-5
Molecular Formula	C53H83N17O14S
Molecular Weight	1182.4 g/mol
Synonyms	Ala(6)-GRP(14-23); [Ala6]-GRP(14-23); GRP(14-23), Ala(6)-; H-Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-OH (sequence); Bombesin (6-14), Ala(6)-; Neuromedin C (6-14), Ala(6)-; Synthetic GRP fragment analog; Ala6-Gastrin Releasing Peptide (10)
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality systems. Each batch of Gastrin-Releasing Peptide 10, Ala(6)- undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.