Description

C-Desmethyl Metoprolol CAS NO 109632-08-8 is a key pharmaceutical intermediate and metabolite of the widely used β-blocker, Metoprolol. This compound is of significant importance in analytical chemistry and drug development for method validation, pharmacokinetic studies, and impurity profiling. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in quality control and regulatory compliance for cardiovascular medications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of Metoprolol and its related substances in drug products and biological matrices.
• Metabolite Studies: Essential for in-vitro and in-vivo pharmacokinetic research to understand the metabolism, distribution, and excretion pathways of Metoprolol.
• Impurity Profiling: Serves as a critical impurity marker in the development and validation of analytical methods to ensure the purity and safety of Metoprolol active pharmaceutical ingredients (APIs).
• Method Development & Validation: Employed in HPLC, LC-MS, and GC-MS method development to establish specificity, accuracy, and detection limits for Metoprolol assays.
• Clinical Research: Utilized in bioanalytical studies to correlate drug metabolite levels with therapeutic efficacy and side effects.
• Quality Control (QC) Testing: Acts as a system suitability standard in routine QC laboratories to ensure the performance of chromatographic systems for Metoprolol-based drug formulations.

Basic Information

Product Name	C-Desmethyl Metoprolol
CAS No.	109632-08-8
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	Desmethyl Metoprolol; 1-(4-(2-Methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol; Metoprolol Desmethyl Impurity; Metoprolol Metabolite; O-Desmethyl Metoprolol (isomeric); 4'-(2-Hydroxy-3-(isopropylamino)propoxy)-3'-methoxy phenyl ethanol; 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol
EINECS	Contact for details

Quality Control

Our C-Desmethyl Metoprolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profile is provided with every shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.