Description

(+)-trans-(1R,2R)-U-50488 Hydrochloride is a highly selective and potent κ-opioid receptor (KOR) agonist, widely recognized as a critical pharmacological research tool. Its primary value lies in its stereochemical purity, which is essential for studying receptor-specific signaling pathways and physiological effects in neuroscience and pain management research. This compound is indispensable for pharmaceutical R&D, academic institutions, and contract research organizations (CROs) focused on neuropharmacology, analgesia, and substance abuse research.

Application

• Neuroscience Research: Used as a standard KOR agonist to study receptor function, signaling cascades, and neural circuitry in vitro and in vivo.
• Analgesic Mechanism Studies: Investigates κ-opioid mediated pain relief pathways for the development of novel, non-addictive analgesics.
• Psychopharmacology: A key tool for researching the role of the κ-opioid system in mood, stress response, and psychiatric disorders.
• Drug Discovery & Development: Serves as a reference compound for screening and validating new KOR-targeted drug candidates.
• Substance Abuse Research: Employed to study the effects and mechanisms of KOR agonists related to dysphoria and potential for abuse.
• Biochemical Assays: Used in receptor binding assays and functional tests (e.g., GTPγS) to characterize compound affinity and efficacy.

Basic Information

Product Name	(+)-trans-(1R,2R)-U-50488 Hydrochloride
CAS No.	109620-49-7
Molecular Formula	C19H28ClNO2 • HCl
Molecular Weight	374.35 g/mol
Synonyms	U-50488 Hydrochloride; (1R,2R)-U-50488 Hydrochloride; trans-U-50488 Hydrochloride; (+)-U-50488 Hydrochloride; (1R,2R)-2-(3,4-Dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide Hydrochloride; U-50488H; Kappa Opioid Receptor Agonist U-50488
EINECS	Contact for details

Quality Control

Our (+)-trans-(1R,2R)-U-50488 Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for advanced research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral purity. We adhere to relevant standards for research chemicals, and custom purity grades or analytical testing are available upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under anhydrous conditions and handled in a manner that minimizes exposure to light and atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.