Description

Calmodulin (8-13) CAS NO 109612-89-7 is a synthetic peptide fragment corresponding to residues 8-13 of the calcium-binding regulatory protein calmodulin. This specific sequence is crucial for studying protein-protein interactions, calcium signaling pathways, and the development of enzyme inhibitors. It is primarily utilized by researchers and developers in the fields of biochemistry, molecular biology, and pharmaceutical discovery. The compound serves as a vital tool for investigating the mechanisms of calcium-mediated cellular processes and for high-throughput screening applications.

Application

• Biochemical Research: Used as a reference standard and active probe in studies of calmodulin-dependent enzyme regulation and calcium signal transduction.
• Pharmaceutical Development: Serves as a key intermediate or template for designing and screening novel therapeutic agents that modulate calmodulin activity.
• Enzyme Inhibition Studies: Employed to investigate and characterize the inhibition of kinases, phosphatases, and other enzymes regulated by calmodulin.
• Diagnostic Reagent Manufacturing: Utilized in the production of assay kits and reagents for research and clinical diagnostics targeting calcium signaling biomarkers.
• Neuroscience Research: Applied in studies exploring the role of calmodulin in neuronal function, synaptic plasticity, and neurodegenerative diseases.
• Cell Biology: Used in cellular assays to visualize or interfere with intracellular calcium signaling events.

Basic Information

Product Name	Calmodulin (8-13)
CAS No.	109612-89-7
Molecular Formula	C34H56N12O9
Molecular Weight	752.89 g/mol
Synonyms	Calmodulin Fragment 8-13; CaM (8-13); H-Lys-Cys-Thr-Thr-Glu-Leu-OH; L-Lysyl-L-cysteinyl-L-threonyl-L-threonyl-L-α-glutamyl-L-leucine; Calmodulin Binding Domain Peptide (8-13); CaMBP (8-13); CaM Inhibitor Peptide (8-13)
EINECS	Contact for details

Quality Control

Our Calmodulin (8-13) is produced under stringent conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and MS for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.