Description

Hirudin (55-65) (Sulfated) is a potent, naturally occurring thrombin-specific inhibitor derived from the salivary glands of medicinal leeches. This sulfated variant, with a molecular weight range of 55-65 kDa, offers enhanced stability and specific activity for advanced research and development applications. It is a critical raw material for pharmaceutical companies, diagnostic manufacturers, and life science researchers focused on hemostasis, thrombosis, and cardiovascular disease. Our product is supplied to meet the stringent demands of high-purity biochemical applications.

Application

• Anticoagulant Drug Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the research and formulation of novel antithrombotic therapies.
• Diagnostic Reagents: Used in the manufacture of coagulation test kits and assays to measure thrombin activity, prothrombin time (PT), and activated partial thromboplastin time (aPTT).
• Biochemical Research: An essential tool for studying the mechanisms of blood coagulation, platelet aggregation, and thrombin-inhibitor interactions in vitro.
• Medical Device Coatings: Applied to surfaces of stents, catheters, and other blood-contacting medical devices to impart antithrombogenic properties.
• Standard for Quality Control: Employed as a purity and activity standard in the quality control laboratories of pharmaceutical and diagnostic industries.

Basic Information

Product Name	Hirudin (55-65) (Sulfated)
CAS No.	109528-50-9
Molecular Formula	Contact for details
Molecular Weight	55,000 - 65,000 Da
Synonyms	Hirudin Sulfate; Hirudin (Sulfated Form); Leech Hirudin; Thrombin Inhibitor (Hirudin); Hirudin Variant 2 (Hirv2); Recombinant Hirudin (sulfated); Anticoagulant Protein from Hirudo medicinalis; Natural Thrombin Inhibitor
EINECS	Contact for details

Quality Control

Our Hirudin (55-65) (Sulfated) is produced and tested under a rigorous quality management system. Each batch is characterized for identity, purity, and biological activity using advanced analytical techniques including HPLC, SDS-PAGE, and chromogenic substrate assays. We provide comprehensive Certificates of Analysis (COA) detailing all test results, ensuring traceability and compliance with research and cGMP-grade material standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (SDS-PAGE)	≥ 95%
Assay (Antithrombin Activity)	≥ 12,000 ATU/mg
Protein Content (UV)	≥ 90%
Water Content (KF)	≤ 5.0 %
Endotoxin	< 10 EU/mg
Biological Activity Test	Pass

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.