Description

Adenosine 3'-Phosphate 5'-Phosphosulfate Lithium Salt is a high-purity, biologically active nucleotide cofactor essential for enzymatic sulfation reactions. This compound serves as the universal sulfate donor for all cytosolic sulfotransferase (SULT) enzymes, making it a critical reagent in biochemical research and pharmaceutical development. It is primarily utilized by researchers in drug metabolism studies, enzymology, and by manufacturers developing high-throughput screening assays for sulfotransferase activity.

Application

• Biochemical Research: Essential cofactor for in vitro studies of sulfotransferase (SULT) enzyme kinetics, inhibition, and substrate specificity.
• Drug Metabolism & Toxicology: Used to investigate Phase II sulfation pathways of pharmaceuticals, xenobiotics, and endogenous compounds to assess metabolic fate and detoxification.
• Diagnostic Assay Development: Key component in the formulation of kits and reagents for measuring sulfotransferase activity in clinical and research settings.
• Enzyme Characterization: Serves as the sulfate donor for the purification, characterization, and functional analysis of recombinant and native sulfotransferases.
• High-Throughput Screening (HTS): Utilized in drug discovery campaigns to identify modulators (activators or inhibitors) of sulfotransferase enzymes for therapeutic targeting.
• Biosynthesis Studies: Applied in the enzymatic synthesis of sulfated metabolites, hormones (e.g., steroid sulfates), and other biologically important sulfated molecules.

Basic Information

Product Name	Adenosine 3'-Phosphate 5'-Phosphosulfate Lithium Salt
CAS No.	109434-21-1
Molecular Formula	C10H12Li4N5O13P2S
Molecular Weight	527.09 g/mol (Lithium salt form)
Synonyms	PAPS, Lithium Salt; 3'-Phosphoadenosine-5'-phosphosulfate Lithium Salt; Adenosine 3',5'-Bisphosphate Sulfate Lithium Salt; PAPS Li Salt; 3'-Phosphoadenylyl Sulfate Lithium; Adenosine 3'-Phosphate 5'-Phosphosulfate Tetralithium Salt; Sulfoadenosine Phosphate Lithium Salt
EINECS	Contact for details

Quality Control

Our Adenosine 3'-Phosphate 5'-Phosphosulfate Lithium Salt is manufactured under controlled conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95%
Assay (Enzymatic)	≥ 90% (as PAPS)
Water Content (KF)	≤ 5.0%
Biological Activity	Suitable for use as a sulfotransferase cofactor

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.