Description

(R)-1-Boc-3-Hydroxypyrrolidine is a high-value, chiral building block extensively used in asymmetric synthesis. This compound is critical for introducing the (R)-3-hydroxypyrrolidine moiety, a privileged scaffold found in numerous bioactive molecules. It is an essential intermediate for pharmaceutical researchers and manufacturers developing active pharmaceutical ingredients (APIs), particularly in the areas of neurology, virology, and oncology.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other complex drug candidates.
• Asymmetric Synthesis: Used as a precursor for chiral ligands, catalysts, and auxiliaries in stereoselective transformations.
• API Development: Core building block in the research and commercial production of Active Pharmaceutical Ingredients (APIs).
• Peptidomimetics: Integral for constructing proline and hydroxyproline analogs in peptide-based drug discovery.
• Agrochemicals: Intermediate in the synthesis of advanced, chiral agrochemicals requiring specific stereochemistry.
• Academic & R&D: Serves as a standard reagent in medicinal chemistry and organic synthesis research laboratories.

Basic Information

Product Name	(R)-1-Boc-3-Hydroxypyrrolidine
CAS No.	109431-87-0
Molecular Formula	C9H17NO3
Molecular Weight	187.24 g/mol
Synonyms	(R)-3-Hydroxypyrrolidine-1-carboxylic acid tert-butyl ester; (R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine; (R)-N-Boc-3-hydroxypyrrolidine; (R)-1-Boc-3-pyrrolidinol; tert-Butyl (R)-3-hydroxypyrrolidine-1-carboxylate; (R)-3-Hydroxy-1-Boc-pyrrolidine; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidin-3-ol
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-3-Hydroxypyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.