Description

23-Hydroxybudesonide is a key pharmaceutical intermediate and metabolite of the anti-inflammatory corticosteroid budesonide. This compound is of significant interest for research and development in the synthesis of advanced steroid-based therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on respiratory and inflammatory diseases. The high-purity material is essential for analytical reference standards and process development.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of novel corticosteroid drugs and prodrugs.
• Analytical Reference Standard: Used in HPLC, LC-MS, and other analytical methods for the quantification and qualification of budesonide and its metabolites in biological and pharmaceutical samples.
• Metabolite Studies: Essential for pharmacokinetic, pharmacodynamic, and drug metabolism research related to budesonide therapy.
• Process Development & Validation: Serves as a benchmark in the development and quality control of budesonide manufacturing processes.
• Research Chemical: Used in biochemical and pharmacological research to study steroid receptor interactions and metabolic pathways.

Basic Information

Product Name	23-Hydroxybudesonide
CAS No.	109423-03-2
Molecular Formula	C₂₅H₃₄O₇
Molecular Weight	446.53 g/mol
Synonyms	16α,17α-Butylidenebis(oxy)-11β,21-dihydroxy-23-hydroxypregna-1,4-diene-3,20-dione; 23-Hydroxy Budesonide; Budesonide Impurity F (EP); Budesonide 23-Hydroxy Derivative; 23-OH-Budesonide; Budesonide Metabolite; (11β,16α)-16,17-Butylidenebis(oxy)-11,21,23-trihydroxypregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our 23-Hydroxybudesonide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets high-grade pharmaceutical standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.