Description

Captopril n-Ethylmaleimide Sulfoxide is a key chemical intermediate and a derivative of the active pharmaceutical ingredient Captopril. This compound is of significant importance for research and development in medicinal chemistry, particularly in the study of enzyme inhibition and drug metabolism. It serves as a critical building block for pharmaceutical scientists and researchers focused on cardiovascular and renal therapeutics, as well as for manufacturers developing high-purity active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Primary use as a high-value synthetic intermediate in the production and research of Captopril and related angiotensin-converting enzyme (ACE) inhibitors.
• Biochemical Research: Used as a specialized reagent in proteomics and enzymology studies, particularly for investigating thiol-dependent enzyme mechanisms.
• Reference Standard: Serves as a certified reference material (CRM) or analytical standard for quality control and method development in pharmaceutical laboratories.
• Metabolite Studies: Employed in the synthesis and identification of drug metabolites for pharmacokinetic and pharmacodynamic research.
• Process Chemistry: Utilized in route scouting and optimization for the scalable synthesis of complex sulfur-containing pharmaceutical molecules.

Basic Information

Product Name	Captopril n-Ethylmaleimide Sulfoxide
CAS No.	109350-29-0
Molecular Formula	C14H18N2O5S2
Molecular Weight	358.43 g/mol
Synonyms	1-[(2S)-3-Mercapto-2-methyl-1-oxopropanyl]-L-proline N-Ethylmaleimide Sulfoxide; N-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline N-Ethylmaleimide Sulfoxide; Captopril NEM Sulfoxide; Captopril Maleimide Sulfoxide; N-Ethylmaleimide Derivative of Captopril Sulfoxide; ACE Inhibitor Derivative; L-Proline, N-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-, N-ethylmaleimide sulfoxide
EINECS	Contact for details

Quality Control

Our Captopril n-Ethylmaleimide Sulfoxide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.