Description

3-Buten-2-One, 4-Butoxy-1,1,1-Trifluoro-, (3E)- is a specialized fluorinated α,β-unsaturated ketone, a versatile building block prized for its unique trifluoromethyl and alkoxy-substituted olefinic structure. This compound is critical for introducing fluorinated motifs into target molecules, significantly altering their physicochemical properties such as lipophilicity, metabolic stability, and binding affinity. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the development of novel drug candidates, particularly in creating trifluoromethylated bioactive molecules for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and emission efficiency.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific properties like chemical resistance, low surface energy, or altered refractive index.
• Organic Synthesis & Catalysis: Employed in Michael addition reactions, cycloadditions, and as a ligand precursor in organometallic chemistry for asymmetric synthesis.
• Fluorinated Surfactant & Coating Agent: Used to synthesize surface-active agents and coatings that require oil- and water-repellent characteristics.

Basic Information

Product Name	3-Buten-2-One, 4-Butoxy-1,1,1-Trifluoro-, (3E)-
CAS No.	109317-78-4
Molecular Formula	C8H11F3O2
Molecular Weight	196.17 g/mol
Synonyms	(3E)-4-Butoxy-1,1,1-trifluorobut-3-en-2-one; 4-Butoxy-1,1,1-trifluoro-3-buten-2-one (E)-; 1,1,1-Trifluoro-4-butoxy-3-buten-2-one; (E)-4-Butoxy-1,1,1-trifluorobut-3-en-2-one; 4-Butoxy-1,1,1-trifluorobut-3-en-2-one; (E)-4-Butoxy-1,1,1-trifluoro-3-buten-2-one; Trifluoromethyl vinyl ketone butyl ether; Butyl (E)-4,4,4-trifluoro-3-oxobut-1-enyl ether
EINECS	Contact for details

Quality Control

Our production of 3-Buten-2-One, 4-Butoxy-1,1,1-Trifluoro-, (3E)- adheres to a stringent quality management system. Every batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR, MS), to ensure high purity and consistent isomeric composition. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Isomeric Purity (E/Z Ratio)	≥ 98:2 (E:Z)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.