Description

5'-((Homocysteinyl)Methyl)Adenosine 5'-(Beta,γ-Imidotriphosphate) is a chemically modified nucleotide analog, specifically a homocysteine-adenosine conjugate linked to a non-hydrolyzable imidotriphosphate moiety. This compound is of significant value as a potent biochemical tool for studying enzyme mechanisms, particularly those involving S-adenosylmethionine (SAM) and ATP-dependent processes. It is primarily required by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers engaged in epigenetics, metabolic pathway analysis, and inhibitor development.

Application

• Biochemical Research: As a stable analog and potential inhibitor for methyltransferases and other SAM/ATP-utilizing enzymes in mechanistic studies.
• Enzymology Studies: Investigation of substrate specificity and catalytic mechanisms of kinases, synthetases, and transferases.
• Pharmaceutical Development: Screening for novel therapeutic agents targeting epigenetic regulation and one-carbon metabolism pathways.
• Diagnostic Reagent Formulation: Potential use as a key component in assay kits for measuring enzyme activity or metabolite levels.
• Metabolic Pathway Analysis: Probing homocysteine metabolism and related transsulfuration or remethylation cycles in cellular models.
• Structural Biology: Co-crystallization with target proteins to elucidate binding sites and modes of action via X-ray crystallography.

Basic Information

Product Name	5'-((Homocysteinyl)Methyl)Adenosine 5'-(Beta,γ-Imidotriphosphate)
CAS No.	109214-84-8
Molecular Formula	C16H24N8O12P3S
Molecular Weight	669.41 g/mol
Synonyms	5'-S-[(3-Amino-3-carboxypropyl)methyl]-5'-thioadenosine 5'-(β,γ-imidotriphosphate); Homocysteine-adenosine imidotriphosphate conjugate; AdoHcy-Imido-PPP; 5'-[(Homocysteinyl)methyl]adenosine 5'-(β,γ-imidotriphosphate); SAM analog, imidotriphosphate; Non-hydrolyzable SAM/ATP hybrid analog; 5'-Deoxy-5'-[(3-amino-3-carboxypropyl)methylthio]adenosine 5'-(β,γ-imidotriphosphate)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade biochemicals. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing purity, HPLC chromatograms, and NMR/LC-MS data are available upon request. We adhere to a strict quality management system to guarantee batch-to-batch consistency and reliable performance in your sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water or buffer, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.