Description

Boc-L-Cyclohexylglycine is a protected, non-proteinogenic amino acid derivative of significant value in advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex peptides and peptidomimetics, offering precise control over molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing novel therapeutic agents and bioactive compounds.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for metabolic and neurological targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the sterically hindered cyclohexylglycine residue, which can enhance peptide stability and modulate biological activity.
• Peptidomimetic Design: Essential for creating non-peptide compounds that mimic the structure and function of natural peptides, improving metabolic stability and oral bioavailability.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified amino acids for studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Potential use as a building block in the synthesis of novel herbicides or pesticides with specific chiral requirements.
• Academic & Industrial R&D: Serves as a valuable reagent for methodological development in asymmetric synthesis and for creating custom compound libraries for high-throughput screening.

Basic Information

Product Name	Boc-L-Cyclohexylglycine
CAS No.	109183-71-3
Molecular Formula	C₁₃H₂₃NO₄
Molecular Weight	257.33 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-2-cyclohexylacetic acid; N-(tert-Butoxycarbonyl)-L-cyclohexylglycine; Boc-Cyh-OH; Boc-L-2-Amino-2-cyclohexylacetic acid; N-Boc-L-cyclohexylglycine; (S)-2-(tert-Butoxycarbonylamino)-2-cyclohexylacetic acid; tert-Butyloxycarbonyl-L-cyclohexylglycine; L-Cyclohexylglycine, N-Boc-protected
EINECS	Contact for details

Quality Control

Our Boc-L-Cyclohexylglycine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.