Description

Piroxicam o-β-D-Glucuronide is a major Phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) piroxicam. This compound is of significant value in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It serves as a critical reference standard for analytical method development and validation in bioanalytical laboratories. Researchers in drug metabolism, toxicology, and clinical pharmacology require this high-purity metabolite to understand drug clearance pathways and potential interactions.

Application

• Pharmaceutical Reference Standard: Primary use as an analytical standard for quantifying piroxicam and its metabolites in biological matrices (plasma, urine) via HPLC, LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the glucuronidation pathway, metabolic stability, and excretion profiles of piroxicam.
• Bioanalytical Method Development: Used to calibrate instruments and validate assays for accuracy, precision, and specificity in compliance with GLP guidelines.
• Toxicological Research: Employed in studies assessing the safety profile and potential toxicity of piroxicam metabolites.
• Clinical Research: Supports studies on patient variability in drug metabolism and the impact of genetic polymorphisms on piroxicam glucuronidation.
• Impurity Profiling: Acts as a known impurity or degradation product reference in the quality control of piroxicam active pharmaceutical ingredient (API).

Basic Information

Product Name	Piroxicam o-β-D-Glucuronide
CAS No.	108929-12-0
Molecular Formula	C20H23N3O10S
Molecular Weight	497.48 g/mol
Synonyms	Piroxicam O-β-D-Glucuronide; Piroxicam Glucuronide; Piroxicam 1-O-β-D-Glucuronide; 4-Hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1-β-D-Glucopyranuronoside; Piroxicam β-D-Glucuronide; Felden Glucuronide; CP-16171 Glucuronide; Piroxicam O-Glucuronide
EINECS	Contact for details

Quality Control

Our Piroxicam o-β-D-Glucuronide is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch undergoes comprehensive testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, related substances, and residual solvents. Our quality commitment ensures the material is suitable for use as a reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.