Description

H-Glu(Otbu)-Nh2 Hcl is a protected amino acid derivative, specifically the tert-butyl ester hydrochloride salt of glutamine. This compound is a crucial building block in the synthesis of complex peptides and active pharmaceutical ingredients (APIs), offering enhanced solubility and stability during coupling reactions. It is primarily required by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in solid-phase peptide synthesis (SPPS) and medicinal chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected glutamine derivative for the controlled assembly of peptide chains.
• Pharmaceutical Intermediate: Used in the research and production of therapeutic peptides and protein-based drugs.
• Medicinal Chemistry: Serves as a building block for creating novel drug candidates and modifying peptide structures to improve pharmacokinetics.
• Bioconjugation: Employed in the chemical modification of proteins and other biomolecules for diagnostic or therapeutic purposes.
• Chemical Biology Research: Utilized in studying protein-protein interactions and enzyme mechanisms.
• Fine Chemical Synthesis: An intermediate for synthesizing more complex, specialized organic molecules.

Basic Information

Product Name	H-Glu(Otbu)-Nh2 Hcl
CAS No.	108607-02-9
Molecular Formula	C9H19N2O3·HCl
Molecular Weight	254.72 g/mol
Synonyms	L-Glutamine, N2-(tert-butoxycarbonyl)-, 1-tert-butyl ester hydrochloride; Boc-Gln-OtBu·HCl; N-α-Boc-L-glutamine 1-tert-butyl ester hydrochloride; (S)-2-((tert-Butoxycarbonyl)amino)-4-carbamoylbutanoic acid tert-butyl ester hydrochloride; Boc-L-Glutamine-OtBu hydrochloride; H-Gln-OtBu HCl; Glutamine derivative Boc-Gln-OtBu·HCl
EINECS	Contact for details

Quality Control

Our H-Glu(Otbu)-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric purity, and identity confirmation by IR and NMR. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated or nitrogen-purged environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.